UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. 1)*
Agios Pharmaceuticals, Inc.
(Name of Issuer)
Common Stock
(Title of Class of Securities)
00847X104
(CUSIP Number)
December 30, 2016
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
[X] Rule 13d-1(b)
[ ] Rule 13d-1(c)
[ ] Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information
which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities
Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of
the Act (however, see the Notes).
CUSIP: 00847X104 Page 1 of 7
1 NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Capital International Investors **
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE
INSTRUCTIONS) (a)
(b)
3 SEC USE ONLY
4 CITIZENSHIP OR PLACE OF ORGANIZATION
California
5 SOLE VOTING POWER
3,739,823
6 SHARED VOTING POWER
NUMBER OF
SHARES NONE
BENEFICIALL
Y OWNED BY
7 SOLE DISPOSITIVE POWER
EACH
REPORTING 4,205,223
PERSON
WITH:
8 SHARED DISPOSITIVE POWER
NONE
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
4,205,223 Beneficial ownership disclaimed pursuant to Rule
13d-4
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS)
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
10.0%
12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
IA
** A division of Capital Research and Management Company (CRMC)
CUSIP: 00847X104 Page 2 of 7
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549
Schedule 13G
Under the Securities Exchange Act of 1934
Amendment No. 1
Item 1(a) Name of Issuer:
Agios Pharmaceuticals, Inc.
Item 1(b) Address of Issuer's Principal Executive Offices:
88 Sidney Street
Cambridge, MA 02139
Item 2(a) Name of Person(s) Filing:
Capital International Investors, division of Capital Research
and Management Company
Item 2(b) Address of Principal Business Office or, if none,
Residence:
11100 Santa Monica Boulevard
16th Floor
Los Angeles, CA 90025
Item 2(c) Citizenship: N/A
Item 2(d) Title of Class of Securities:
Common Stock
Item 2(e) CUSIP Number:
00847X104
Item 3 If this statement is filed pursuant to sections 240.13d-1(b)
or 240.13d-2(b) or (c), check whether the person filing is a:
(e) [X] An investment adviser in accordance with
section 240.13d-1(b)(1)(ii)(E).
Item 4 Ownership
Provide the following information regarding the aggregate
number and percentage of the class of securities of the issuer
identified in Item 1.
(a) Amount beneficially owned:
(b) Percent of class:
(c) Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
(ii) Shared power to vote or to direct the vote:
(iii) Sole power to dispose or to direct the disposition of:
(iv) Shared power to dispose or to direct the disposition of:
See page 2
Capital International Investors division of Capital Research
and Management Company ("CRMC") and the following CRMC
subsidiaries: Capital Guardian Trust Company, Capital
International Limited, Capital International Sarl, Capital
International K.K. and Capital International, Inc.,
CUSIP: 00847X104 Page 3 of 7
collectively provide investment management services under the
name "Capital International Investors." Please see Items 5
through 11 of each reporting person's cover sheet in this
Schedule 13G filing for such person's deemed beneficial
ownership of 4,205,223 shares or 10% of the 42,014,777 shares
believed to be outstanding.
Item 5 Ownership of Five Percent or Less of a Class. If this
statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial
owner of more than five percent of the class of securities,
check the following: [ ]
Item 6 Ownership of More than Five Percent on Behalf of Another
Person: N/A
Item 7 Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on By the Parent Holding
Company or Control Person: N/A
Item 8 Identification and Classification of Members of the Group:
N/A
Item 9 Notice of Dissolution of Group: N/A
Item 10 Certification
By signing below, I certify that, to the best of my knowledge
and belief, the securities referred to above were acquired and
are held in the ordinary course of business and were not
acquired and are not held for the purpose of or with the effect
of changing or influencing the control of the issuer of the
securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose
or effect.
Signature
After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this
statement is true, complete and correct.
Date: January 9, 2017
Signature: **Robert W. Lovelace
Name/Title: Robert W. Lovelace, Partner
Capital International Investors
***By /s/ Walter R. Burkley
Walter R. Burkley
Attorney-in-fact
Signed pursuant to a Power of Attorney dated January 4, 2017
included as an Exhibit to Schedule 13G filed with the
Securities and Exchange Commission by Capital International
Investors.
CUSIP: 00847X104 Page 4 of 7
EXHIBIT
POWER OF ATTORNEY
The undersigned do hereby appoint Michael J. Downer, Kristine
M. Nishiyama and Walter R. Burkley, and each of them, acting singly,
with full power of substitution, as the true and lawful attorney of the
undersigned, to sign on behalf of the undersigned in respect of the
ownership of equity securities deemed held by the undersigned, Capital
International Investors, Capital Group International, Inc., Capital
Guardian Trust Company, Capital International, Inc., Capital
International K.K., Capital International Limited, Capital
International Sarl, American Funds Developing World Growth and Income
Fund, American Funds Insurance Series (Capital Income Builder and
Growth-Income Fund), American Mutual Fund, Capital Income Builder,
Capital World Growth and Income Fund, Emerging Markets Growth Fund,
Inc., International Growth and Income Fund, New Perspective Fund, New
World Fund, Inc., and Washington Mutual Investors Fund, and to be
reported pursuant to Sections 13(d), 13(f) and 13(g) of the Securities
Exchange Act of 1934, as amended, and to execute joint filing
agreements with respect to such filings.
IN WITNESS WHEREOF, this Power of Attorney has been executed
th
as of the 4 day of January, 2017.
CUSIP: 00847X104 Page 5 of 7
Capital International Investors
/s/Robert W. Lovelace
Name: Robert W. Lovelace
Title: Partner
Capital Group International, Inc.
/s/ Peter C. Kelly
Name: Peter C. Kelly
Title: Secretary
Capital Guardian Trust Company
/s/ Peter C. Kelly
Name: Peter C. Kelly
Title: President and Senior Counsel
Capital International, Inc.
/s/ Peter C. Kelly
Name: Peter C. Kelly
Title: Senior Vice President and Senior
Counsel
Capital International K.K.
/s/ Thomas B. Quantrille
Name: Thomas B. Quantrille
Title: President
Capital International Limited
/s/ Ida Levine
Name: Ida Levine
Title: Senior Vice President
CUSIP: 00847X104 Page 6 of 7
Capital International Sarl
/s/ Guido Caratsch
Name: Guido Caratsch
Title: Vice President, Senior Counsel and
Secretary
American Mutual Fund
/s/ Laurie D. Neat
Name: Laurie D. Neat
Title: Secretary
American Funds Developing World Growth and
Income Fund
Capital Income Builder
Capital World Growth and Income Fund
International Growth and Income Fund
New Perspective Fund
New World Fund, Inc.
/s/ Michael W. Stockton
Name: Michael W. Stockton
Title: Secretary
American Funds Insurance Series
/s/ Steven I. Koszalka
Name: Steven I. Koszalka
Title: Secretary
Emerging Markets Growth Fund, Inc.
/s/ Courtney R. Taylor
Name: Courtney R. Taylor
Title: Secretary
Washington Mutual Investors Fund
/s/ Michael W. Stockton
Name: Michael W. Stockton
CUSIP: 00847X104 Page 7 of 7